5VZS

BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)

5VZS の概要

• エントリーDOI: 10.2210/pdb5vzs/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, ... (4 entities in total)
• 機能のキーワード: brd4, bromodomain, small molecule inhibitor, transcription regulator-inhibitor complex, transcription regulator/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38651.89

構造登録者

Murray, J.M. (登録日: 2017-05-29, 公開日: 2018-05-30, 最終更新日: 2023-10-04)

• 主引用文献: Murray, J.M.; GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of CBP/P300; To be published,

実験手法

X-RAY DIFFRACTION (1.707 Å)