5VZA

Pre-catalytic ternary complex of human Polymerase Mu (G433S) mutant with incoming nonhydrolyzable UMPNPP

Summary for 5VZA

• Entry DOI: 10.2210/pdb5vza/pdb
• Related: 5TWP 5TWQ 5TWR 5TWS
• Descriptor: DNA-directed DNA/RNA polymerase mu, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... (9 entities in total)
• Functional Keywords: family x, nonhomologous end-joining, dna double strand break repair, ribonucleotide incorporation, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 45676.54

Authors

Moon, A.F.,Pryor, J.M.,Ramsden, D.A.,Kunkel, T.A.,Bebenek, K.,Pedersen, L.C. (deposition date: 2017-05-27, release date: 2017-07-05, Last modification date: 2023-10-04)

• Primary citation: Moon, A.F.,Pryor, J.M.,Ramsden, D.A.,Kunkel, T.A.,Bebenek, K.,Pedersen, L.C.; Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.; Nucleic Acids Res., 45:9138-9148, 2017; PubMed: 28911097; DOI: 10.1093/nar/gkx527

Experimental method

X-RAY DIFFRACTION (1.501 Å)