5VWX

Bak core latch dimer in complex with Bim-h0-h3Glt

5VWX の概要

• エントリーDOI: 10.2210/pdb5vwx/pdb
• 分子名称: Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: apoptosis, bcl-2 family, inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 43831.00

構造登録者

Brouwer, J.M.,Lan, P.,Lessene, G.,Colman, P.M.,Czabotar, P.E. (登録日: 2017-05-23, 公開日: 2017-11-15, 最終更新日: 2020-01-08)

• 主引用文献: Brouwer, J.M.,Lan, P.,Cowan, A.D.,Bernardini, J.P.,Birkinshaw, R.W.,van Delft, M.F.,Sleebs, B.E.,Robin, A.Y.,Wardak, A.,Tan, I.K.,Reljic, B.,Lee, E.F.,Fairlie, W.D.,Call, M.J.,Smith, B.J.,Dewson, G.,Lessene, G.,Colman, P.M.,Czabotar, P.E.; Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.; Mol. Cell, 68:659-672.e9, 2017; PubMed: 29149594; DOI: 10.1016/j.molcel.2017.11.001

実験手法

X-RAY DIFFRACTION (2.489 Å)