5VWR

E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)-alpha-ketoglutarate

5VWR の概要

• エントリーDOI: 10.2210/pdb5vwr/pdb
• 関連するPDBエントリー: 5VWO 5VWQ
• 分子名称: Aspartate aminotransferase, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: aspartate aminotransferase, mechanism-based inactivator, ketimine, (1r, 3s, 4s)-3-amino-4-fluorocyclopentane-1-carboxylic acid (fcp), alpha-ketoglutarate, transferase
• 由来する生物種: Escherichia coli (strain K12)
• 細胞内の位置: Cytoplasm: P00509
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44455.94

構造登録者

Mascarenhas, R.,Liu, D.,Le, H.,Silverman, R. (登録日: 2017-05-22, 公開日: 2017-09-13, 最終更新日: 2024-03-13)

• 主引用文献: Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D.; Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.; Biochemistry, 56:4951-4961, 2017; PubMed: 28816437; DOI: 10.1021/acs.biochem.7b00499

実験手法

X-RAY DIFFRACTION (1.72 Å)