5VWO

Ornithine aminotransferase inactivated by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP)

5VWO の概要

• エントリーDOI: 10.2210/pdb5vwo/pdb
• 関連するPDBエントリー: 5VWQ 5VWR
• 分子名称: Ornithine aminotransferase, mitochondrial, (1S,3S,4E)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid (3 entities in total)
• 機能のキーワード: aminotransferase, mechanism-based inactivator, plp, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 135655.81

構造登録者

Mascarenhas, R.,Liu, D.,Le, H.,Silverman, R. (登録日: 2017-05-22, 公開日: 2017-08-30, 最終更新日: 2023-10-04)

• 主引用文献: Mascarenhas, R.,Le, H.V.,Clevenger, K.D.,Lehrer, H.J.,Ringe, D.,Kelleher, N.L.,Silverman, R.B.,Liu, D.; Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.; Biochemistry, 56:4951-4961, 2017; PubMed: 28816437; DOI: 10.1021/acs.biochem.7b00499

実験手法

X-RAY DIFFRACTION (1.773 Å)