5VSK

Structure of DUB complex

5VSK の概要

• エントリーDOI: 10.2210/pdb5vsk/pdb
• 分子名称: Ubiquitin carboxyl-terminal hydrolase 7, 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, ZINC ION, ... (4 entities in total)
• 機能のキーワード: deubiquitinase, inhibitor, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q93009
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83150.19

構造登録者

Seo, H.-Y.,Dhe-Paganon, S. (登録日: 2017-05-11, 公開日: 2017-12-20, 最終更新日: 2018-01-03)

• 主引用文献: Lamberto, I.,Liu, X.,Seo, H.S.,Schauer, N.J.,Iacob, R.E.,Hu, W.,Das, D.,Mikhailova, T.,Weisberg, E.L.,Engen, J.R.,Anderson, K.C.,Chauhan, D.,Dhe-Paganon, S.,Buhrlage, S.J.; Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.; Cell Chem Biol, 24:1490-1500.e11, 2017; PubMed: 29056421; DOI: 10.1016/j.chembiol.2017.09.003

実験手法

X-RAY DIFFRACTION (3.33 Å)