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5VQQ

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide (JLJ683), a Non-nucleoside Inhibitor

Summary for 5VQQ
Entry DOI10.2210/pdb5vqq/pdb
Related5TER 5VQR 5VQS 5VQT 5VQU 5VQV 5VQW 5VQX 5VQY 5VQZ
DescriptorReverse transcriptase/ribonuclease H, p51 RT, N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide, ... (5 entities in total)
Functional Keywordspolymerase, reverse transcriptase, non-nucleoside inhibitor, transferase-hydrolase-inhibitor complex, transferase/hydrolase/inhibitor
Biological sourceHuman immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
More
Total number of polymer chains2
Total formula weight114627.28
Authors
Chan, A.H.,Anderson, K.S. (deposition date: 2017-05-09, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citationChan, A.H.,Lee, W.G.,Spasov, K.A.,Cisneros, J.A.,Kudalkar, S.N.,Petrova, Z.O.,Buckingham, A.B.,Anderson, K.S.,Jorgensen, W.L.
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Proc. Natl. Acad. Sci. U.S.A., 114:9725-9730, 2017
Cited by
PubMed: 28827354
DOI: 10.1073/pnas.1711463114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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