5VPS
Crystal structure of an SDR from Burkholderia ambifaria in complex with NADPH with a TCEP adduct
5VPS の概要
エントリーDOI | 10.2210/pdb5vps/pdb |
分子名称 | Short-chain dehydrogenase/reductase SDR, [(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]piperidin-4-yl]-tris(3-hydroxy-3-oxopropyl)phosphanium, 1,2-ETHANEDIOL, ... (4 entities in total) |
機能のキーワード | sgcid, short chain, dehydrogenase, reductase, nadp, nadph, tcep, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase |
由来する生物種 | Burkholderia ambifaria (strain MC40-6) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 28767.20 |
構造登録者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2017-05-05, 公開日: 2017-05-24, 最終更新日: 2023-10-04) |
主引用文献 | Patel, S.M.,Smith, T.G.,Morton, M.,Stiers, K.M.,Seravalli, J.,Mayclin, S.J.,Edwards, T.E.,Tanner, J.J.,Becker, D.F. Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes. Biochemistry, 2020 Cited by PubMed: 32841567DOI: 10.1021/acs.biochem.0c00490 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.45 Å) |
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