5VOC

Crystal structure of HCMV Pentamer in complex with neutralizing antibody 8I21 - Low resolution dataset for initial phasing by SAD

5VOC の概要

• エントリーDOI: 10.2210/pdb5voc/pdb
• 関連するPDBエントリー: 5VOB 5VOD
• 分子名称: Envelope glycoprotein H, Envelope glycoprotein L, Envelope glycoprotein UL128, ... (9 entities in total)
• 機能のキーワード: hcmv, neutralizing epitope, immunogen, viral entry, pentamer, vaccine, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human cytomegalovirus (HHV-5); 詳細
• 細胞内の位置: Virion membrane ; Single-pass type I membrane protein : Q6SW67; Virion membrane ; Peripheral membrane protein ; Extracellular side : Q68674; Virion : F5HET4
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 234995.93

構造登録者

Malito, E.,Chandramouli, S. (登録日: 2017-05-02, 公開日: 2017-07-05, 最終更新日: 2020-07-29)

• 主引用文献: Chandramouli, S.,Malito, E.,Nguyen, T.,Luisi, K.,Donnarumma, D.,Xing, Y.,Norais, N.,Yu, D.,Carfi, A.; Structural basis for potent antibody-mediated neutralization of human cytomegalovirus.; Sci Immunol, 2:-, 2017; PubMed: 28783665; DOI: 10.1126/sciimmunol.aan1457

実験手法

X-RAY DIFFRACTION (3.99 Å)