5VOC

Crystal structure of HCMV Pentamer in complex with neutralizing antibody 8I21 - Low resolution dataset for initial phasing by SAD

Summary for 5VOC

Entry DOI	10.2210/pdb5voc/pdb
Related	5VOB 5VOD
Descriptor	Envelope glycoprotein H, Envelope glycoprotein L, Envelope glycoprotein UL128, ... (9 entities in total)
Functional Keywords	hcmv, neutralizing epitope, immunogen, viral entry, pentamer, vaccine, immune system, viral protein-immune system complex, viral protein/immune system
Biological source	Human cytomegalovirus (HHV-5) More
Cellular location	Virion membrane ; Single-pass type I membrane protein : Q6SW67 Virion membrane ; Peripheral membrane protein ; Extracellular side : Q68674 Virion : F5HET4
Total number of polymer chains	7
Total formula weight	234995.93
Authors	Malito, E.,Chandramouli, S. (deposition date: 2017-05-02, release date: 2017-07-05, Last modification date: 2020-07-29)
Primary citation	Chandramouli, S.,Malito, E.,Nguyen, T.,Luisi, K.,Donnarumma, D.,Xing, Y.,Norais, N.,Yu, D.,Carfi, A. Structural basis for potent antibody-mediated neutralization of human cytomegalovirus. Sci Immunol, 2:-, 2017 Cited by PubMed: 28783665 DOI: 10.1126/sciimmunol.aan1457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.99 Å)

Structure validation