5VO6
CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRIDAZINE INHIBITOR
Summary for 5VO6
Entry DOI | 10.2210/pdb5vo6/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 4-{[(1R,3S)-3-amino-2,2,3-trimethylcyclopentyl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide (3 entities in total) |
Functional Keywords | transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 1 |
Total formula weight | 33631.50 |
Authors | Sack, J.S. (deposition date: 2017-05-02, release date: 2017-05-31, Last modification date: 2024-03-13) |
Primary citation | Hynes, J.,Wu, H.,Kempson, J.,Duan, J.J.,Lu, Z.,Jiang, B.,Stachura, S.,Tokarski, J.S.,Sack, J.S.,Khan, J.A.,Lippy, J.S.,Zhang, R.F.,Pitt, S.,Shen, G.,Gillooly, K.,McIntyre, K.,Carter, P.H.,Barrish, J.C.,Nadler, S.G.,Salter-Cid, L.M.,Fura, A.,Schieven, G.L.,Pitts, W.J.,Wrobleski, S.T. Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. Bioorg. Med. Chem. Lett., 27:3101-3106, 2017 Cited by PubMed: 28539220DOI: 10.1016/j.bmcl.2017.05.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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