5VO4

Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With 5-(2-fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

Summary for 5VO4

Entry DOI	10.2210/pdb5vo4/pdb
Descriptor	Androgen receptor, 5-(2-fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile (3 entities in total)
Functional Keywords	receptor, small molecule inhibitor, hormone receptor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P10275
Total number of polymer chains	1
Total formula weight	29390.41
Authors	Parris, K.,Unwalla, R. (deposition date: 2017-05-02, release date: 2018-03-14, Last modification date: 2024-03-13)
Primary citation	Unwalla, R.,Mousseau, J.J.,Fadeyi, O.O.,Choi, C.,Parris, K.,Hu, B.,Kenney, T.,Chippari, S.,McNally, C.,Vishwanathan, K.,Kilbourne, E.,Thompson, C.,Nagpal, S.,Wrobel, J.,Yudt, M.,Morris, C.A.,Powell, D.,Gilbert, A.M.,Chekler, E.L.P. Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators. J. Med. Chem., 60:6451-6457, 2017 Cited by PubMed: 28696695 DOI: 10.1021/acs.jmedchem.7b00373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation