5VME

Crystal structure of human IgG1 Fc K248E, T437R mutant

Summary for 5VME

• Entry DOI: 10.2210/pdb5vme/pdb
• Descriptor: human IgG1 Fc K248E,T437R mutant, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: fc, immunoglobulin fold, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 53094.55

Authors

Armstrong, A.A.,Gilliland, G.L. (deposition date: 2017-04-27, release date: 2017-08-30, Last modification date: 2023-10-04)

• Primary citation: Zhang, D.,Armstrong, A.A.,Tam, S.H.,McCarthy, S.G.,Luo, J.,Gilliland, G.L.,Chiu, M.L.; Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.; MAbs, 9:1129-1142, 2017; PubMed: 28758875; DOI: 10.1080/19420862.2017.1358838

Experimental method

X-RAY DIFFRACTION (3.1 Å)