5VJA

Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)

5VJA の概要

• エントリーDOI: 10.2210/pdb5vja/pdb
• 分子名称: Death-associated protein kinase 3, DIMETHYL SULFOXIDE, (2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide, ... (5 entities in total)
• 機能のキーワード: death-associated protein kinase 3, transferase, inhibitor, smooth muscle contraction, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132023.38

構造登録者

Carlson, D.A.,Singer, M.R.,Sutherland, C.,Redondo, C.,Alexander, L.,Hughes, P.F.,Knapp, S.,MacDonald, J.A.,Haystead, T.A.J. (登録日: 2017-04-19, 公開日: 2018-08-08, 最終更新日: 2023-10-04)

• 主引用文献: Carlson, D.A.,Singer, M.R.,Sutherland, C.,Redondo, C.,Alexander, L.T.,Hughes, P.F.,Knapp, S.,Gurley, S.B.,Sparks, M.A.,MacDonald, J.A.,Haystead, T.A.J.; Targeting Pim Kinases and DAPK3 to Control Hypertension.; Cell Chem Biol, 25:1195-, 2018; PubMed: 30033129; DOI: 10.1016/j.chembiol.2018.06.006

実験手法

X-RAY DIFFRACTION (2.46 Å)