5VI9
Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitors
Summary for 5VI9
Entry DOI | 10.2210/pdb5vi9/pdb |
Related | 5VHB 5VIB |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, PKI peptide, N-[(3-fluorophenyl)methyl]-6-(pyridin-4-yl)-1,3-benzothiazol-2-amine, ... (4 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Bos taurus (Bovine) More |
Cellular location | Cytoplasm : P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43066.21 |
Authors | Judge, R.A. (deposition date: 2017-04-14, release date: 2018-01-31, Last modification date: 2018-04-04) |
Primary citation | Judge, R.A.,Vasudevan, A.,Scott, V.E.,Simler, G.H.,Pratt, S.D.,Namovic, M.T.,Putman, C.B.,Aguirre, A.,Stoll, V.S.,Mamo, M.,Swann, S.I.,Cassar, S.C.,Faltynek, C.R.,Kage, K.L.,Boyce-Rustay, J.M.,Hobson, A.D. Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate. Chembiochem, 19:613-621, 2018 Cited by PubMed: 29314498DOI: 10.1002/cbic.201700547 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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