5VH4

Crystal structure of Fab fragment of anti-TNFa antibody infliximab in an I-centered orthorhombic crystal form

5VH4 の概要

• エントリーDOI: 10.2210/pdb5vh4/pdb
• 関連するPDBエントリー: 5VH3 5VH5
• 分子名称: Infliximab Fab Heavy Chain, Infliximab Fab Light Chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: antibody, fab, biosimilar, infliximab, tnfa, anti-tnfa, immune system
• 由来する生物種: Mus musculus, Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 97271.29

構造登録者

Mayclin, S.J.,Edwards, T.E.,Lerch, T.F.,Conlan, H.,Sharpe, P. (登録日: 2017-04-12, 公開日: 2017-05-03, 最終更新日: 2023-10-04)

• 主引用文献: Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Lee, E.,Conlon, H.D.,Polleck, S.,Rouse, J.C.,Luo, Y.,Zou, Q.; Infliximab crystal structures reveal insights into self-association.; MAbs, 9:874-883, 2017; PubMed: 28421849; DOI: 10.1080/19420862.2017.1320463

実験手法

X-RAY DIFFRACTION (2 Å)