5VH3

Crystal structure of Fab fragment of the anti-TNFa antibody infliximab in a C-centered orthorhombic crystal form

Summary for 5VH3

Entry DOI	10.2210/pdb5vh3/pdb
Related	5VH4 5VH5
Descriptor	Infliximab Fab Heavy Chain, Infliximab Fab Light Chain, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	antibody, fab, infliximab, biosimilar, tnfa, immune system
Biological source	Mus musculus More
Total number of polymer chains	4
Total formula weight	95696.17
Authors	Mayclin, S.J.,Edwards, T.E.,Lerch, T.F.,Conlan, H.,Sharpe, P. (deposition date: 2017-04-12, release date: 2017-05-03, Last modification date: 2023-10-04)
Primary citation	Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Lee, E.,Conlon, H.D.,Polleck, S.,Rouse, J.C.,Luo, Y.,Zou, Q. Infliximab crystal structures reveal insights into self-association. MAbs, 9:874-883, 2017 Cited by PubMed: 28421849 DOI: 10.1080/19420862.2017.1320463 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation