5VFC

WDR5 bound to inhibitor MM-589

5VFC の概要

• エントリーDOI: 10.2210/pdb5vfc/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002270
• 分子名称: WD repeat-containing protein 5, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, wd repeat, transcription, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35336.08

構造登録者

Stuckey, J.A. (登録日: 2017-04-07, 公開日: 2017-06-28, 最終更新日: 2024-03-13)

• 主引用文献: Karatas, H.,Li, Y.,Liu, L.,Ji, J.,Lee, S.,Chen, Y.,Yang, J.,Huang, L.,Bernard, D.,Xu, J.,Townsend, E.C.,Cao, F.,Ran, X.,Li, X.,Wen, B.,Sun, D.,Stuckey, J.A.,Lei, M.,Dou, Y.,Wang, S.; Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.; J. Med. Chem., 60:4818-4839, 2017; PubMed: 28603984; DOI: 10.1021/acs.jmedchem.6b01796

実験手法

X-RAY DIFFRACTION (1.64 Å)