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5VEX

Structure of the human GLP-1 receptor complex with NNC0640

Summary for 5VEX
Entry DOI10.2210/pdb5vex/pdb
Related5VEW
DescriptorGlucagon-like peptide 1 receptor, Endolysin chimera, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide (2 entities in total)
Functional Keywordsgpcr, class b, 7tm domain, treatment of type 2 diabetes, signaling protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Multi-pass membrane protein: P43220
Total number of polymer chains2
Total formula weight106321.83
Authors
Primary citationSong, G.,Yang, D.,Wang, Y.,de Graaf, C.,Zhou, Q.,Jiang, S.,Liu, K.,Cai, X.,Dai, A.,Lin, G.,Liu, D.,Wu, F.,Wu, Y.,Zhao, S.,Ye, L.,Han, G.W.,Lau, J.,Wu, B.,Hanson, M.A.,Liu, Z.J.,Wang, M.W.,Stevens, R.C.
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546:312-315, 2017
Cited by
PubMed: 28514449
DOI: 10.1038/nature22378
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

217705

数据于2024-03-27公开中

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