5VEX

Structure of the human GLP-1 receptor complex with NNC0640

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glucagon-like peptide 1 receptor, Endolysin chimera	polymer	455	52587.3	2	UniProt (P43220) UniProt (P00720) Pfam (PF00002) Pfam (PF00959) In PDB	Homo sapiens (Human)	GLP-1R,Lysis protein,Lysozyme,Muramidase
2	A, B	4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide	non-polymer		573.7	2	Chemie (97V)

Sequence modifications

A, B: 128 - 257 (UniProt: P43220)

PDB	External Database	Details
Ser 127	-	expression tag
Cys 193	Ser 193	engineered mutation
Phe 196	Ile 196	engineered mutation
Gly 212	Tyr 205	linker
-	Thr 207	deletion
-	Ala 208	deletion
-	Ala 209	deletion
-	Gln 210	deletion
-	Gln 211	deletion
-	His 212	deletion
-	Gln 213	deletion
Gly 214	Trp 214	linker
Ala 225	Ser 225	engineered mutation
Csd 233	Met 233	engineered mutation

A, B: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Gly 1012	Arg 12	engineered mutation
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation
Arg 1137	Ile 137	engineered mutation

A, B: 261 - 431 (UniProt: P43220)

PDB	External Database	Details
Ala 271	Ser 271	engineered mutation
Cys 317	Ile 317	engineered mutation
Ile 318	Gly 318	engineered mutation
Ala 346	Lys 346	engineered mutation
Phe 347	Cys 347	engineered mutation
Cys 361	Gly 361	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105174.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1147.3
All*	Total formula weight	106321.8

*Water molecules are not included.