5VAR
Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor
Summary for 5VAR
Entry DOI | 10.2210/pdb5var/pdb |
Descriptor | Lysine-specific demethylase 4A, (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol (3 entities in total) |
Functional Keywords | kdm4a tandem tudor domain, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13788.26 |
Authors | Judge, R.A.,Upadhyay, A.K. (deposition date: 2017-03-27, release date: 2018-03-28, Last modification date: 2023-10-04) |
Primary citation | Upadhyay, A.K.,Judge, R.A.,Li, L.,Pithawalla, R.,Simanis, J.,Bodelle, P.M.,Marin, V.L.,Henry, R.F.,Petros, A.M.,Sun, C. Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach. Bioorg. Med. Chem. Lett., 28:1708-1713, 2018 Cited by PubMed: 29691138DOI: 10.1016/j.bmcl.2018.04.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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