5VAR

Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor

5VAR の概要

• エントリーDOI: 10.2210/pdb5var/pdb
• 分子名称: Lysine-specific demethylase 4A, (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol (3 entities in total)
• 機能のキーワード: kdm4a tandem tudor domain, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13788.26

構造登録者

Judge, R.A.,Upadhyay, A.K. (登録日: 2017-03-27, 公開日: 2018-03-28, 最終更新日: 2023-10-04)

• 主引用文献: Upadhyay, A.K.,Judge, R.A.,Li, L.,Pithawalla, R.,Simanis, J.,Bodelle, P.M.,Marin, V.L.,Henry, R.F.,Petros, A.M.,Sun, C.; Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.; Bioorg. Med. Chem. Lett., 28:1708-1713, 2018; PubMed: 29691138; DOI: 10.1016/j.bmcl.2018.04.050

実験手法

X-RAY DIFFRACTION (1.83 Å)