5V9L
KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder
Summary for 5V9L
Entry DOI | 10.2210/pdb5v9l/pdb |
Related | 5V9O |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kras mutant inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 3 |
Total formula weight | 60678.71 |
Authors | Westover, K.,Lu, J. (deposition date: 2017-03-23, release date: 2017-08-23, Last modification date: 2023-10-04) |
Primary citation | Zeng, M.,Lu, J.,Li, L.,Feru, F.,Quan, C.,Gero, T.W.,Ficarro, S.B.,Xiong, Y.,Ambrogio, C.,Paranal, R.M.,Catalano, M.,Shao, J.,Wong, K.K.,Marto, J.A.,Fischer, E.S.,Janne, P.A.,Scott, D.A.,Westover, K.D.,Gray, N.S. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol, 24:1005-1016.e3, 2017 Cited by PubMed: 28781124DOI: 10.1016/j.chembiol.2017.06.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.981 Å) |
Structure validation
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