5V8Q

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III

Summary for 5V8Q

Entry DOI	10.2210/pdb5v8q/pdb
Descriptor	Androgen receptor, GLYCEROL, 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, ... (4 entities in total)
Functional Keywords	androgen receptor, selective androgen receptor modulators, sarms, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P10275
Total number of polymer chains	1
Total formula weight	29562.51
Authors	Wilson, K.P. (deposition date: 2017-03-22, release date: 2017-05-24, Last modification date: 2017-11-22)
Primary citation	Aikawa, K.,Asano, M.,Ono, K.,Habuka, N.,Yano, J.,Wilson, K.,Fujita, H.,Kandori, H.,Hara, T.,Morimoto, M.,Santou, T.,Yamaoka, M.,Nakayama, M.,Hasuoka, A. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg. Med. Chem., 25:3330-3349, 2017 Cited by PubMed: 28454849 DOI: 10.1016/j.bmc.2017.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.44 Å)

Structure validation