5V8O
Discovery of a high affinity inhibitor of cGAS
Summary for 5V8O
Entry DOI | 10.2210/pdb5v8o/pdb |
Related | 5V8H 5V8J 5V8N |
Descriptor | Cyclic GMP-AMP synthase, ZINC ION, 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol, ... (4 entities in total) |
Functional Keywords | cgas, sting, cgamp, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol . Note=(Microbial infection) Upon infection with virulent M: Q8N884 |
Total number of polymer chains | 2 |
Total formula weight | 85580.22 |
Authors | Hall, J. (deposition date: 2017-03-22, release date: 2017-09-27, Last modification date: 2024-03-06) |
Primary citation | Hall, J.,Brault, A.,Vincent, F.,Weng, S.,Wang, H.,Dumlao, D.,Aulabaugh, A.,Aivazian, D.,Castro, D.,Chen, M.,Culp, J.,Dower, K.,Gardner, J.,Hawrylik, S.,Golenbock, D.,Hepworth, D.,Horn, M.,Jones, L.,Jones, P.,Latz, E.,Li, J.,Lin, L.L.,Lin, W.,Lin, D.,Lovering, F.,Niljanskul, N.,Nistler, R.,Pierce, B.,Plotnikova, O.,Schmitt, D.,Shanker, S.,Smith, J.,Snyder, W.,Subashi, T.,Trujillo, J.,Tyminski, E.,Wang, G.,Wong, J.,Lefker, B.,Dakin, L.,Leach, K. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12:e0184843-e0184843, 2017 Cited by PubMed: 28934246DOI: 10.1371/journal.pone.0184843 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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