5V8O
Discovery of a high affinity inhibitor of cGAS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cyclic GMP-AMP synthase | polymer | 362 | 42404.9 | 2 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F, G (A, B) | 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol | non-polymer | 213.2 | 3 | Chemie (8ZM) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84809.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 770.4 | |
| All* | Total formula weight | 85580.2 |
