6NFG

CYCLIC GMP-AMP SYNTHASE in complex with compound 16 inhibitor: 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

Replaces:  5V8H

Summary for 6NFG

• Entry DOI: 10.2210/pdb6nfg/pdb
• Related: 5V8J 5V8N 5V8O
• Descriptor: CYCLIC GMP-AMP SYNTHASE, ZINC ION, 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: cgas, sting, cgamp, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 85477.17

Authors

Hall, J. (deposition date: 2018-12-20, release date: 2019-01-23, Last modification date: 2024-03-13)

• Primary citation: Hall, J.; Discovery of a high affinity inhibitor of cGAS; to be published,

Experimental method

X-RAY DIFFRACTION (2.76 Å)