6NFG

CYCLIC GMP-AMP SYNTHASE in complex with compound 16 inhibitor: 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

Replaces:  5V8H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CYCLIC GMP-AMP SYNTHASE	polymer	362	42404.9	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266)	Homo sapiens (Human)	h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	C, E (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, F (A, B)	7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide	non-polymer		268.3	2	Chemie (KKP)
4	G, H (A, B)	water	water		18.0	177	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84809.8
Non-Polymers*	Number of molecules	4
	Total formula weight	667.4
All*	Total formula weight	85477.2

*Water molecules are not included.