5V71

KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder

Summary for 5V71

• Entry DOI: 10.2210/pdb5v71/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kras, covalent inhibitor, quinazoline based, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 6
• Total formula weight: 120672.54

Authors

Westover, K.,Lu, J. (deposition date: 2017-03-17, release date: 2017-08-23, Last modification date: 2023-10-04)

• Primary citation: Lu, J.,Harrison, R.A.,Li, L.,Zeng, M.,Gondi, S.,Scott, D.,Gray, N.S.,Engen, J.R.,Westover, K.D.; KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.; Structure, 25:1442-1448.e3, 2017; PubMed: 28781083; DOI: 10.1016/j.str.2017.07.003

Experimental method

X-RAY DIFFRACTION (2.228 Å)