5V6U

Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-[(2-acetylphenyl)sulfanyl]benzoic acid

Summary for 5V6U

• Entry DOI: 10.2210/pdb5v6u/pdb
• Related: 5V6Z
• Descriptor: Caspase-7, 2-[(2-acetylphenyl)sulfanyl]benzoic acid (3 entities in total)
• Functional Keywords: hydrolase, protease, inhibitor, allosteric, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P55210
• Total number of polymer chains: 2
• Total formula weight: 68919.98

Authors

Vance, N.R.,Gakhar, L.,Spies, M.A. (deposition date: 2017-03-17, release date: 2017-10-18, Last modification date: 2023-10-04)

• Primary citation: Vance, N.R.,Gakhar, L.,Spies, M.A.; Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach.; Angew. Chem. Int. Ed. Engl., 56:14443-14447, 2017; PubMed: 28940929; DOI: 10.1002/anie.201706959

Experimental method

X-RAY DIFFRACTION (2.8 Å)