Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5V6U

Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-[(2-acetylphenyl)sulfanyl]benzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0007507	biological_process	heart development
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0009411	biological_process	response to UV
A	0016485	biological_process	protein processing
A	0030163	biological_process	protein catabolic process
A	0042742	biological_process	defense response to bacterium
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044346	biological_process	fibroblast apoptotic process
A	0051146	biological_process	striated muscle cell differentiation
A	0051402	biological_process	neuron apoptotic process
A	0051604	biological_process	protein maturation
A	0070227	biological_process	lymphocyte apoptotic process
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071887	biological_process	leukocyte apoptotic process
A	0072734	biological_process	cellular response to staurosporine
A	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
A	0097194	biological_process	execution phase of apoptosis
A	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
A	1905686	biological_process	positive regulation of plasma membrane repair
B	0003723	molecular_function	RNA binding
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0007507	biological_process	heart development
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0009411	biological_process	response to UV
B	0016485	biological_process	protein processing
B	0030163	biological_process	protein catabolic process
B	0042742	biological_process	defense response to bacterium
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0044346	biological_process	fibroblast apoptotic process
B	0051146	biological_process	striated muscle cell differentiation
B	0051402	biological_process	neuron apoptotic process
B	0051604	biological_process	protein maturation
B	0070227	biological_process	lymphocyte apoptotic process
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071887	biological_process	leukocyte apoptotic process
B	0072734	biological_process	cellular response to staurosporine
B	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
B	0097194	biological_process	execution phase of apoptosis
B	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
B	1905686	biological_process	positive regulation of plasma membrane repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 8YM B 401

Chain	Residue
B	LYS160
B	HOH501
B	HOH531
B	THR163
B	ALA164
B	ARG167
B	GLU216
B	PHE219
B	PHE221
B	TYR223
B	MET294

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HtnaaCfaCiLLSHG

Chain	Residue	Details
A	HIS131-GLY145

site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKLFFIQACRG

Chain	Residue	Details
A	LYS177-GLY188

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:15314233

Chain	Residue	Details
A	TYR111
B	TYR111

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:11701129, ECO:0000269\|PubMed:15314233, ECO:0000269\|PubMed:16916640

Chain	Residue	Details
A	LYS153
B	LYS153

site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Cleavage; by CAPN1 => ECO:0000269\|PubMed:19617626

Chain	Residue	Details
A	ASP3
A	GLY12
A	GLU14
B	ASP3
B	GLY12
B	GLU14

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Involved in allosteric regulation => ECO:0000269\|PubMed:15314233, ECO:0000269\|PubMed:19581639

Chain	Residue	Details
A	ASP154
A	GLU190
B	ASP154
B	GLU190

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	ASP4
B	ASP4

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PAK2 => ECO:0000269\|PubMed:21555521, ECO:0000269\|PubMed:27889207

Chain	Residue	Details
A	ILE140
B	ILE140

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269\|PubMed:35338844, ECO:0000269\|PubMed:35446120

Chain	Residue	Details
A	GLY200
B	GLY200

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000269\|PubMed:21555521, ECO:0000269\|PubMed:27889207

Chain	Residue	Details
A	ASP206
B	ASP206

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)