5V5E

Room temperature (280K) crystal structure of Kaposi's sarcoma-associated herpesvirus protease in complex with allosteric inhibitor (compound 733)

Summary for 5V5E

Entry DOI	10.2210/pdb5v5e/pdb
Related	5V5D
Descriptor	ORF 17, 4-{[6-(cyclohexylmethyl)pyridine-2-carbonyl]amino}-3-{[3-(trifluoromethoxy)phenyl]amino}benzoic acid (3 entities in total)
Functional Keywords	protease, allosteric inhibitor, herpesvirus, viral protein - inhibitor complex, viral protein / inhibitor
Biological source	Human herpesvirus 8 (HHV-8)
Total number of polymer chains	2
Total formula weight	43926.75
Authors	Thompson, M.C.,Acker, T.M.,Fraser, J.S.,Craik, C.S. (deposition date: 2017-03-14, release date: 2017-04-12, Last modification date: 2023-10-04)
Primary citation	Acker, T.M.,Gable, J.E.,Bohn, M.F.,Jaishankar, P.,Thompson, M.C.,Fraser, J.S.,Renslo, A.R.,Craik, C.S. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. J. Am. Chem. Soc., 139:11650-11653, 2017 Cited by PubMed: 28759216 DOI: 10.1021/jacs.7b04030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.299 Å)

Structure validation