5V4N
Structure of HLA-DR1 with bound alpha3(135-145) peptide
Summary for 5V4N
Entry DOI | 10.2210/pdb5v4n/pdb |
Descriptor | HLA-DRA1, alpha3(135-145)-HLA-DRB1*01:01, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | hla-dr, immune complex, antigen presenation, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P01903 P04229 |
Total number of polymer chains | 4 |
Total formula weight | 93721.64 |
Authors | Petersen, J.,Rossjohn, J. (deposition date: 2017-03-10, release date: 2017-05-03, Last modification date: 2023-10-04) |
Primary citation | Ooi, J.D.,Petersen, J.,Tan, Y.H.,Huynh, M.,Willett, Z.J.,Ramarathinam, S.H.,Eggenhuizen, P.J.,Loh, K.L.,Watson, K.A.,Gan, P.Y.,Alikhan, M.A.,Dudek, N.L.,Handel, A.,Hudson, B.G.,Fugger, L.,Power, D.A.,Holt, S.G.,Coates, P.T.,Gregersen, J.W.,Purcell, A.W.,Holdsworth, S.R.,La Gruta, N.L.,Reid, H.H.,Rossjohn, J.,Kitching, A.R. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature, 545:243-247, 2017 Cited by PubMed: 28467828DOI: 10.1038/nature22329 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.405 Å) |
Structure validation
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