5V4N

Structure of HLA-DR1 with bound alpha3(135-145) peptide

5V4N の概要

• エントリーDOI: 10.2210/pdb5v4n/pdb
• 分子名称: HLA-DRA1, alpha3(135-145)-HLA-DRB1*01:01, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: hla-dr, immune complex, antigen presenation, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93721.64

構造登録者

Petersen, J.,Rossjohn, J. (登録日: 2017-03-10, 公開日: 2017-05-03, 最終更新日: 2023-10-04)

• 主引用文献: Ooi, J.D.,Petersen, J.,Tan, Y.H.,Huynh, M.,Willett, Z.J.,Ramarathinam, S.H.,Eggenhuizen, P.J.,Loh, K.L.,Watson, K.A.,Gan, P.Y.,Alikhan, M.A.,Dudek, N.L.,Handel, A.,Hudson, B.G.,Fugger, L.,Power, D.A.,Holt, S.G.,Coates, P.T.,Gregersen, J.W.,Purcell, A.W.,Holdsworth, S.R.,La Gruta, N.L.,Reid, H.H.,Rossjohn, J.,Kitching, A.R.; Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.; Nature, 545:243-247, 2017; PubMed: 28467828; DOI: 10.1038/nature22329

実験手法

X-RAY DIFFRACTION (3.405 Å)