5V3H

Crystal structure of SMYD2 with SAM and EPZ033294

5V3H の概要

• エントリーDOI: 10.2210/pdb5v3h/pdb
• 関連するPDBエントリー: 5V37
• 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION, ... (8 entities in total)
• 機能のキーワード: protein-inhibitor complex, protein lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52905.31

構造登録者

Boriack-Sjodin, P.A. (登録日: 2017-03-07, 公開日: 2018-04-25, 最終更新日: 2024-03-06)

• 主引用文献: Thomenius, M.J.,Totman, J.,Harvey, D.,Mitchell, L.H.,Riera, T.V.,Cosmopoulos, K.,Grassian, A.R.,Klaus, C.,Foley, M.,Admirand, E.A.,Jahic, H.,Majer, C.,Wigle, T.,Jacques, S.L.,Gureasko, J.,Brach, D.,Lingaraj, T.,West, K.,Smith, S.,Rioux, N.,Waters, N.J.,Tang, C.,Raimondi, A.,Munchhof, M.,Mills, J.E.,Ribich, S.,Porter Scott, M.,Kuntz, K.W.,Janzen, W.P.,Moyer, M.,Smith, J.J.,Chesworth, R.,Copeland, R.A.,Boriack-Sjodin, P.A.; Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.; Plos One, 13:e0197372-e0197372, 2018; PubMed: 29856759; DOI: 10.1371/journal.pone.0197372

実験手法

X-RAY DIFFRACTION (2.69 Å)