5V3H
Crystal structure of SMYD2 with SAM and EPZ033294
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | N-lysine methyltransferase SMYD2 | polymer | 444 | 51028.4 | 1 | UniProt (Q9NRG4) Pfam (PF00856) Pfam (PF01753) In PDB | Homo sapiens (Human) | HSKM-B,Histone methyltransferase SMYD2,Lysine N-methyltransferase 3C,SET and MYND domain-containing protein 2 |
2 | A | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
4 | A | N-[1-({1-[(4-chlorophenyl)methyl]-1H-pyrazol-4-yl}methyl)azetidin-3-yl]-1-cyclopropyl-1H-1,2,3-triazole-4-carboxamide | non-polymer | 411.9 | 2 | Chemie (8WG) | |||
5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
7 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
8 | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 1 - 433 (UniProt: Q9NRG4)
PDB | External Database | Details |
---|---|---|
Ser -10 | - | expression tag |
Ile -9 | - | expression tag |
Ala -8 | - | expression tag |
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 51028.4 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1876.9 | |
All* | Total formula weight | 52905.3 |