5V2I

Crystal structure of a mutant glycosylasparaginase (G172D) that causes the genetic disease Aspartylglucosaminuria

Summary for 5V2I

• Entry DOI: 10.2210/pdb5v2i/pdb
• Descriptor: Glycosylasparaginase (2 entities in total)
• Functional Keywords: beta-aha, catalytic mechanism, hydrolase
• Biological source: Elizabethkingia meningoseptica
• Total number of polymer chains: 2
• Total formula weight: 64475.34

Authors

Pande, S.,Guo, H. (deposition date: 2017-03-04, release date: 2017-05-17, Last modification date: 2023-10-04)

• Primary citation: Pande, S.,Lakshminarasimhan, D.,Guo, H.C.; Crystal structure of a mutant glycosylasparaginase shedding light on aspartylglycosaminuria-causing mechanism as well as on hydrolysis of non-chitobiose substrate.; Mol. Genet. Metab., 121:150-156, 2017; PubMed: 28457719; DOI: 10.1016/j.ymgme.2017.04.008

Experimental method

X-RAY DIFFRACTION (1.83 Å)