5V0U

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4723 4-(5-chlorothiophen-2-yl)-1H-pyrazole

5V0U の概要

• エントリーDOI: 10.2210/pdb5v0u/pdb
• 関連するPDBエントリー: 4iuj 5IEQ 5IF2 5IF5 5IF7 5IF8 5IFB 5IFC 5IFD
• 分子名称: Polymerase acidic protein, 4-(5-chlorothiophen-2-yl)-1H-pyrazole (3 entities in total)
• 機能のキーワード: fragment screening, flu, ppi, protein-protein interface, fbld, fragment-based ligand discovery, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transcription
• 由来する生物種: Influenza A virus (strain A/Wilson-Smith/1933 H1N1)
• 細胞内の位置: Host cytoplasm: P15659
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53281.37

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2017-02-28, 公開日: 2017-03-08, 最終更新日: 2023-10-04)

• 主引用文献: Pierce, P.G.,Muruthii, M.M.,Moen, S.O.,Abendroth, J.,Davies, D.R.,Labaied, M.,Marathias, V.M.,Begley, D.W.,Hokanson, D.,Suto, R.K.,Hubbard, B.K.,Myler, P.J.,Lorimer, D.D.,Edwards, T.E.; Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase; To Be Published,

実験手法

X-RAY DIFFRACTION (2.45 Å)