5UZB

Cryo-EM structure of the MAL TIR domain filament

Summary for 5UZB

• Entry DOI: 10.2210/pdb5uzb/pdb
• EMDB information: 8625
• Descriptor: Toll/interleukin-1 receptor domain-containing adapter protein (1 entity in total)
• Functional Keywords: tir domain, adaptor proteins, tlr signaling, homotypic protein interactions, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 14
• Total formula weight: 275648.27

Authors

Ve, T.,Vajjhala, P.R.,Hedger, A.,Croll, T.,DiMaio, F.,Horsefield, S.,Yu, X.,Lavrencic, P.,Hassan, Z.,Morgan, G.P.,Mansell, A.,Mobli, M.,O'Carrol, A.,Chauvin, B.,Gambin, Y.,Sierecki, E.,Landsberg, M.J.,Stacey, K.J.,Egelman, E.H.,Kobe, B. (deposition date: 2017-02-25, release date: 2017-07-26, Last modification date: 2020-01-15)

• Primary citation: Ve, T.,Vajjhala, P.R.,Hedger, A.,Croll, T.,DiMaio, F.,Horsefield, S.,Yu, X.,Lavrencic, P.,Hassan, Z.,Morgan, G.P.,Mansell, A.,Mobli, M.,O'Carroll, A.,Chauvin, B.,Gambin, Y.,Sierecki, E.,Landsberg, M.J.,Stacey, K.J.,Egelman, E.H.,Kobe, B.; Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.; Nat. Struct. Mol. Biol., 24:743-751, 2017; PubMed: 28759049; DOI: 10.1038/nsmb.3444

Experimental method

ELECTRON MICROSCOPY (7 Å)