5UYS
Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog
Summary for 5UYS
| Entry DOI | 10.2210/pdb5uys/pdb |
| Related | 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ |
| Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-ol, ... (4 entities in total) |
| Functional Keywords | oxidoreductase, steroidogenic |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 226832.61 |
| Authors | Scott, E.E.,Petrunak, E.M. (deposition date: 2017-02-24, release date: 2018-02-28, Last modification date: 2023-10-04) |
| Primary citation | Petrunak, E.M.,Bart, A.G.,Peng, H.M.,Auchus, R.J.,Scott, E.E. Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299:102999-102999, 2023 Cited by PubMed: 36773804DOI: 10.1016/j.jbc.2023.102999 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.392 Å) |
Structure validation
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