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5UWF

Crystal structure of human PDE10A in complex with inhibitor 16d

Summary for 5UWF
Entry DOI10.2210/pdb5uwf/pdb
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 9-[(1S)-2,2-difluorocyclopropane-1-carbonyl]-6-[(4-methoxyphenyl)methyl]-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one, ZINC ION, ... (5 entities in total)
Functional Keywordsphosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q9Y233
Total number of polymer chains2
Total formula weight80087.01
Authors
Xu, R.,Cedervall, E.P.,Sridhar, V.,Barker, R.,Aertgeerts, K. (deposition date: 2017-02-21, release date: 2017-04-26, Last modification date: 2023-10-04)
Primary citationDyck, B.,Branstetter, B.,Gharbaoui, T.,Hudson, A.R.,Breitenbucher, J.G.,Gomez, L.,Botrous, I.,Marrone, T.,Barido, R.,Allerston, C.K.,Cedervall, E.P.,Xu, R.,Sridhar, V.,Barker, R.,Aertgeerts, K.,Schmelzer, K.,Neul, D.,Lee, D.,Massari, M.E.,Andersen, C.B.,Sebring, K.,Zhou, X.,Petroski, R.,Limberis, J.,Augustin, M.,Chun, L.E.,Edwards, T.E.,Peters, M.,Tabatabaei, A.
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
J. Med. Chem., 60:3472-3483, 2017
Cited by
PubMed: 28406621
DOI: 10.1021/acs.jmedchem.7b00302
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.87 Å)
Structure validation

221051

數據於2024-06-12公開中

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