5UWF

Crystal structure of human PDE10A in complex with inhibitor 16d

5UWF の概要

• エントリーDOI: 10.2210/pdb5uwf/pdb
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 9-[(1S)-2,2-difluorocyclopropane-1-carbonyl]-6-[(4-methoxyphenyl)methyl]-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q9Y233
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80087.01

構造登録者

Xu, R.,Cedervall, E.P.,Sridhar, V.,Barker, R.,Aertgeerts, K. (登録日: 2017-02-21, 公開日: 2017-04-26, 最終更新日: 2023-10-04)

• 主引用文献: Dyck, B.,Branstetter, B.,Gharbaoui, T.,Hudson, A.R.,Breitenbucher, J.G.,Gomez, L.,Botrous, I.,Marrone, T.,Barido, R.,Allerston, C.K.,Cedervall, E.P.,Xu, R.,Sridhar, V.,Barker, R.,Aertgeerts, K.,Schmelzer, K.,Neul, D.,Lee, D.,Massari, M.E.,Andersen, C.B.,Sebring, K.,Zhou, X.,Petroski, R.,Limberis, J.,Augustin, M.,Chun, L.E.,Edwards, T.E.,Peters, M.,Tabatabaei, A.; Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.; J. Med. Chem., 60:3472-3483, 2017; PubMed: 28406621; DOI: 10.1021/acs.jmedchem.7b00302

実験手法

X-RAY DIFFRACTION (1.87 Å)