5UWD
Crystal structure of EGFR kinase domain (L858R, T790M, V948R) in complex with the covalent inhibitor CO-1686
Summary for 5UWD
Entry DOI | 10.2210/pdb5uwd/pdb |
Related | 5UGC |
Descriptor | Epidermal growth factor receptor, N-(3-{[2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)propanamide (2 entities in total) |
Functional Keywords | egfr, kinase, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38138.02 |
Authors | Gajiwala, K.S.,Ferre, R.A. (deposition date: 2017-02-21, release date: 2017-10-18, Last modification date: 2017-11-29) |
Primary citation | Niessen, S.,Dix, M.M.,Barbas, S.,Potter, Z.E.,Lu, S.,Brodsky, O.,Planken, S.,Behenna, D.,Almaden, C.,Gajiwala, K.S.,Ryan, K.,Ferre, R.,Lazear, M.R.,Hayward, M.M.,Kath, J.C.,Cravatt, B.F. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. Cell Chem Biol, 24:1388-1400.e7, 2017 Cited by PubMed: 28965727DOI: 10.1016/j.chembiol.2017.08.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.06 Å) |
Structure validation
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