5UVG
Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound
Summary for 5UVG
| Entry DOI | 10.2210/pdb5uvg/pdb |
| Descriptor | Sphingomyelin phosphodiesterase 3,Sphingomyelin phosphodiesterase 3, CALCIUM ION (3 entities in total) |
| Functional Keywords | sphingomyelinase, hydrolase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 41388.54 |
| Authors | Airola, M.V.,Guja, K.E.,Garcia-Diaz, M.,Hannun, Y.A. (deposition date: 2017-02-20, release date: 2017-06-28, Last modification date: 2024-03-06) |
| Primary citation | Airola, M.V.,Shanbhogue, P.,Shamseddine, A.A.,Guja, K.E.,Senkal, C.E.,Maini, R.,Bartke, N.,Wu, B.X.,Obeid, L.M.,Garcia-Diaz, M.,Hannun, Y.A. Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc. Natl. Acad. Sci. U.S.A., 114:E5549-E5558, 2017 Cited by PubMed: 28652336DOI: 10.1073/pnas.1705134114 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.849 Å) |
Structure validation
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