5UV5

Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase

5UV5 の概要

• エントリーDOI: 10.2210/pdb5uv5/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: reverse transcriptase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 229110.14

構造登録者

Kirby, K.A.,Sarafianos, S.G. (登録日: 2017-02-19, 公開日: 2017-08-16, 最終更新日: 2023-10-04)

• 主引用文献: Kirby, K.A.,Myshakina, N.A.,Christen, M.T.,Chen, Y.L.,Schmidt, H.A.,Huber, A.D.,Xi, Z.,Kim, S.,Rao, R.K.,Kramer, S.T.,Yang, Q.,Singh, K.,Parniak, M.A.,Wang, Z.,Ishima, R.,Sarafianos, S.G.; A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.; Antimicrob. Agents Chemother., 61:-, 2017; PubMed: 28760905; DOI: 10.1128/AAC.01351-17

実験手法

X-RAY DIFFRACTION (3 Å)