5UU1

Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to BI-D1870

「5TKX」から置き換えられました

5UU1 の概要

• エントリーDOI: 10.2210/pdb5uu1/pdb
• 分子名称: Serine/threonine-protein kinase VRK2, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one (3 entities in total)
• 機能のキーワード: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37179.65

構造登録者

Counago, R.M.,Bountra, C.,Arruda, P.,Edwards, A.M.,Gileadi, O.,Structural Genomics Consortium (SGC) (登録日: 2017-02-15, 公開日: 2017-03-01, 最終更新日: 2023-10-04)

• 主引用文献: Counago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O.; Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.; Sci Rep, 7:7501-7501, 2017; PubMed: 28790404; DOI: 10.1038/s41598-017-07755-y

実験手法