5UTQ

Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to PUGNAc

Summary for 5UTQ

• Entry DOI: 10.2210/pdb5utq/pdb
• Related: 4G6C 4GNV 4MSS 5UTP
• Descriptor: Beta-hexosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: glycoside hydrolase, gh, family 3, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Burkholderia cenocepacia
• Cellular location: Cytoplasm : A0A125HFC0
• Total number of polymer chains: 2
• Total formula weight: 77135.42

Authors

Vadlamani, G.,Mark, B.L. (deposition date: 2017-02-15, release date: 2017-04-19, Last modification date: 2023-10-04)

• Primary citation: Vadlamani, G.,Stubbs, K.A.,Desire, J.,Bleriot, Y.,Vocadlo, D.J.,Mark, B.L.; Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress beta-lactam antibiotic resistance.; Protein Sci., 26:1161-1170, 2017; PubMed: 28370529; DOI: 10.1002/pro.3166

Experimental method

X-RAY DIFFRACTION (2.2 Å)