5UTP
Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to N-ethylbutyryl-PUGNAc
Summary for 5UTP
| Entry DOI | 10.2210/pdb5utp/pdb |
| Related | 4G6C 4GNV 4MSS 5UTQ |
| Descriptor | Beta-hexosaminidase, N-[(2Z,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-{[(phenylcarbamoyl)oxy]imino}tetrahydro-2H-pyran-3-yl]-2-ethylbutanamide (3 entities in total) |
| Functional Keywords | glycoside hydrolase, family 3, nagz, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Burkholderia cenocepacia |
| Cellular location | Cytoplasm : A0A125HFC0 |
| Total number of polymer chains | 2 |
| Total formula weight | 77052.40 |
| Authors | Vadlamani, G.,Mark, B.L. (deposition date: 2017-02-15, release date: 2017-04-19, Last modification date: 2023-10-04) |
| Primary citation | Vadlamani, G.,Stubbs, K.A.,Desire, J.,Bleriot, Y.,Vocadlo, D.J.,Mark, B.L. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress beta-lactam antibiotic resistance. Protein Sci., 26:1161-1170, 2017 Cited by PubMed: 28370529DOI: 10.1002/pro.3166 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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