5UT4

JAK2 JH2 in complex with NVP-BSK805

Summary for 5UT4

Entry DOI	10.2210/pdb5ut4/pdb
Related	5USY 5USZ 5UT0 5UT1 5UT2 5UT3 5UT5 5UT6
Descriptor	Tyrosine-protein kinase JAK2, 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline, GLYCEROL, ... (5 entities in total)
Functional Keywords	pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33873.83
Authors	Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04)
Primary citation	Newton, A.S.,Deiana, L.,Puleo, D.E.,Cisneros, J.A.,Cutrona, K.J.,Schlessinger, J.,Jorgensen, W.L. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett, 8:614-617, 2017 Cited by PubMed: 28626520 DOI: 10.1021/acsmedchemlett.7b00154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation