5UT0
JAK2 JH2 in complex with AT9283
Summary for 5UT0
Entry DOI | 10.2210/pdb5ut0/pdb |
Related | 5USY 5USZ 5UT1 5UT2 5UT3 5UT4 5UT5 5UT6 |
Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, ... (6 entities in total) |
Functional Keywords | pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33823.76 |
Authors | Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04) |
Primary citation | Puleo, D.E.,Kucera, K.,Hammaren, H.M.,Ungureanu, D.,Newton, A.S.,Silvennoinen, O.,Jorgensen, W.L.,Schlessinger, J. Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Med Chem Lett, 8:618-621, 2017 Cited by PubMed: 28626521DOI: 10.1021/acsmedchemlett.7b00153 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.102 Å) |
Structure validation
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